Dr. A. PARTHIBAN

Project Scientist (Organic and Medicinal Chemistry)




Contact: parthichem84@gmail.com

Education      

2008-2015 Ph.D. (Synthetic Organic and Medicinal Chemistry), Pondicherry University, Puducherry, India.

2007-2018

M.Phil, Chemistry, Pondicherry University, India.

2005-2007

M.Sc, Chemistry, Annamalai University, India.

2002-2005

B.Sc, Chemistry, Arignar Anna Govt. Arts College, Cheyyar, India.

Awards and Achievements

  • Qualified CSIR-NET in Dec 2009 (Council of Scientific and Industrial Research) conducted by Government of India).
  • Qualified GATE-2009 (Graduate Aptitude Test in Engineering) Conducted by Government of India IITs,
Research Interests
  • Development of new synthetic methodologies
  • Synthesis and biological activity of novel heterocyclic compounds
  • C-H bond functionalization
  • One pot multicomponent reactions
  • Isolation and characterization of bioactive compounds from plant resources
  • Development of Novel drugs from marine resources
  • Isolation and characterization of bioactive marine drugs.
Research Experience 

Presently working as a Project Scientist in Medicinal Chemistry at National Centre for Sustainable Coastal Management (NCSCM), Anna University Campus, Chennai, Tamil Nadu, India.

Teaching Experience

Worked as an Assistant Professor in Department of Chemistry, Karpagam Academy of Higher Education (Deemed University), Coimbatore, Tamil Nadu, during the Period of 24-06-2016 to 30-04-2018.

Worked as an Assistant Professor of Chemistry, King Nandhivarman College of Arts and Science, Vandavasi, Tamil Nadu, during the Period of 12-10-2015 to 09-05-2016.

Research Experience
  • Synthesis of highly substituted Hantzsch type 1,4-dihydropyridines and its application towards the synthesis of novel neonicotinoid insecticide
  • Synthesis and anticancer activity of highly functionalized 4H-chromene and its derivatives.
  • Synthesis and antimalarial activity of chloquinoline-4H-chromene conjugates.
  • Buchwald coupling, C-H activation and one pot multicomponent
  • Michael addition and Henry
  • Synthesis of naturally occurring Curcumin anticancer
  • Isolation and Characterization of Marine
  • Synthesis of nanoparticles
Skills and Accomplishments
  • Expertise in multi-gram scale synthesis in organic
  • Development of new methodologies via transition metal
  • Expertise in interpretation of IR, UV, Mass, GC-MS, LC-MS and NMR Spectral
  • Expertise in interpretation of 2D NMR Spectroscopy (HMBC, HSQC, DEPT ).
  • Expertise in separation of compounds through Flash Column Chromatographic technique.
  • Expertise in separation of compounds through High Pressure Liquid Chromatography (HPLC)

Technical Skills

  • NMR spectral analysis, TLC, Flash Column chromatography, GC-MS, LC-MS, FT-IR, purification techniques, crystallization, distillation, and

Publications

  1. One-pot Pseudo three component reaction of nitroketene-N,S-acetals and aldehydes for synthesis of highly functionalized hexa-substituted 1,4-dihydropyridines. Rao, S. P.; Parthiban, A. Org. Bio. Chem. 2014, 12, 6223–6238. (Highlighted in RSC Blogs).
  2. Synthesis, in vitro and in silico anti-malarial activity of chloroquinoline-4H-chromene conjugates. Parthiban, J. Muthukumaran, Ashan Manhas , Kumkum Srivastava, R. Krishna, H. Surya Prakash Rao. Bioorg. Med. Chem. Lett. 2015, 25, 4657–4663. (Top 10 Article)
  3. Design, synthesis, molecular docking and biological evaluation of N– methyl-3-nitro-4- (nitromethyl)-4H-chromen-2-amine derivatives as potential anticancer agents. Parthiban, A.; Muthukumaran, J.; Priya, M.; Jayachandran, S.; Krishna, R.; Rao, H. S. P. Med. Chem. Res. 2014, 23, 642–659.
  4. Design, synthesis, in vitro and in silico anticancer activity of 4H-chromenes with C4-active methine groups. Parthiban, A.; Kumaravel, M.; Muthukumaran, J.; Rukkumani, R.; Krishna, R. Rao, H. S. P. Chem. Res. 2015, 24, 1226–1240.
  5. Synthesis, in vitro and in silico anti-proliferative activity of 4-aryl-4H-chromene derivatives. Parthiban, A.; Muthukumaran, J.; Kumaravel. M.; Rukkumani, R.; Krishna, R.; Rao, S. P. Med. Chem. Res. 2016, 7, 1308–1315.
  6. An X-ray crystallographic study of N-methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine. Muthukumaran, J.; Parthiban, A.; Rao, H. S. P.; Krishna, R. Chem. Crystallogr. 2011, 41, 927–934.
  7. Sustainable Utilization of Molasses towards Green Synthesis of Silver Nanoparticles for Colorimetric Heavy Metal Sensing and Catalytic Applications. G Manjari, A Parthiban, S Saran. Journal of Cluster Science. 2019, 1-9.
  8. Corrosion protection performance of ceria-copolymer bilayer coating on 304 stainless steel in 1 M H2SO4 medium. M. Surendiran and A. Parthiban. AIP Conference Proceedings. 2019, 2117, 020005.
  9. A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem. V. Sachithanandam , P. Lalitha, Parthiban, T. Mageswaran, K. Manmadhan. Evidence-Based Complementary and Alternative Medicine. 2019, Article ID 4305148.
  10. Indole curcumin reverses multi drug resistance by reducing the expression of ABCB1 and COX2 in induced multidrug resistant human lung cancer cells. Rukkumani R Sankar P., Kumaravel M., Rakesh R., Shamim Sufi, Parthiban A. Letters in Drug Design & Discovery. 2020.
  11. Mn-doped nickeltitanate makes a promising support material methanol oxidation in alkaline medium. Suman R, Parthiban A, Chellasamy V. New Journal of Chemistry (Accepted). 2020.
  12. 1,4-Dihydropyridine: Synthetic advances and their medicinal and agrochemical Applications. Parthiban and P. Makkam. 2020 (Communicated).
  13. Green Synthetic Approach: Synthesis, in vitro and in silico anticancer activity of 1,4- dihydropyridines. Parthiban and P. Makkam. 2020 (Communicated).
  14. Synthesis, In vitro and in silico antibacterial activity of Indole-4H-Chromene A. Parthiban and P. Makkam. 2020 (Communicated).
  15. Phytochemicals speciation of Indian mangroves and their medicinal applications: an Integrative review for a future research perspective. Parthiban, V. Sachithanandam, P. Manmadhan T. Mageswaran & R. Sridhar. 2020 (Communicated).